The appropriate dosing regimens of secukinumab for psoriatic arthritis (PsA) are not well defined. We performed a meta-analysis to evaluate the efficacy and safety of different dosing regimens of secukinumab in the treatment of PsA. A systematic search was conducted using major electronic databases to identify relevant randomized controlled trials (RCTs) comparing secukinumab 300 mg versus secukinumab 150 mg in patients with PsA. Meta-analysis was performed using Review Manager software (version 5.3). Six studies with a total of 1141 patients were included. At week 24, secukinumab 300 mg was associated with a higher American College of Rheumatology 20% response (ACR 20), ACR 50, PASI 75 response rate, and dactylitis resolution rate than secukinumab 150 mg, especially in the anti-TNF-IR subgroup. At week 52, secukinumab 300 mg was associated with a higher psoriasis area and severity index (PASI) 75 and PASI 90 response rate than secukinumab 150 mg. There was no significant difference between secukinumab 300 mg and secukinumab 150 mg in the risk of any adverse events (AEs) and serious AEs at either week 24 or week 52. Secukinumab 300 mg was significantly more effective than 150 mg, especially for patients with PsA who have failed TNF therapy, and it was well tolerated.

This meta-analysis was conducted to evaluate the value of indocyanine green (ICG) in guiding sentinel lymph node biopsy (SLNB) for patients with oral cavity cancer. An electronic database search (PubMed, MEDLINE, Cochrane Library, Embase, and Web of Science) was performed from their inception to June 2020 to retrieve clinical studies of ICG applied to SLNB for oral cavity cancer. Data were extracted from 14 relevant articles (226 patients), and 9 studies (134 patients) were finally included in the meta-analysis according to the inclusion and exclusion criteria. The pooled sentinel lymph node (SLN) sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 88.0% (95% confidence interval [CI], 74.0-96.0), 64.0% (95% CI, 61.0-66.0), 2.45 (95% CI, 1.31-4.60), 0.40 (95% CI, 0.17-0.90), and 7.30 (95% CI, 1.74-30.68), respectively. The area under the summary receiver operating characteristic curve was 0.8805. In conclusion, ICG applied to SLNB can effectively predict the status of regional lymph nodes in oral cavity cancer.

SUMMARY: Thoracic disc herniation (TDH) has high technical difficulty and serious complications, and the clinical anatomy of thoracic intervertebral foramen is less. Collecting 10 adult male cadavers, measuring the longitudinal diameter of the dorsal root ganglion (D1), the transverse diameter of the dorsal root ganglion (D2), horizontal sagittal diameter of the upper edge of the intervertebral disc (S1), the high of intervertebral foramen (H1), the height of articulationes costovertebrales (H2), the height of intervertebral disk (H3), the angel of the dorsal root ganglion (a). The aim of this study is to explore the safe area of middle and lower thoracic section and provide anatomical basis for the selection of operative cannula. Mastering the certain rules of the anatomical structure of the middle and lower thoracic segments, and referring to the above parameters in clinical, is conducive to the selection of the working casing during surgery.

RESUMEN: La hernia de disco torácico (TDH) tiene una alta dificultad técnica y complicaciones graves, y la anatomía clínica del agujero intervertebral torácico es menor. Recolectando 10 cadáveres machos adultos, midiendo el diámetro longitudinal del ganglio de la raíz dorsal (D1), el diámetro transversal del ganglio de la raíz dorsal (D2), el diámetro sagital horizontal del borde superior del disco intervertebral (S1), el colmo del intervertebral agujero (H1), la altura de las articulaciones costovertebrales (H2), la altura del disco intervertebral (H3), el ángel del ganglio de la raíz dorsal (α). El objetivo de este estudio es explorar el área segura de la sección torácica media y baja y proporcionar una base anatómica para la selección de la cánula operatoria. Dominar ciertas reglas de la estructura anatómica de los segmentos torácicos medio e inferior, y referirse a los parámetros anteriores en clínica, es propicio para la selección de la carcasa de trabajo durante la cirugía.

Abstract A novel two-step process of Cr-Mn pack cementation and thermal oxidation was applied to fabricate a MnCr2O4 spinel coating on HP 40 alloy. The Cr-Mn diffusion layer formed after the Cr-Mn pack cementation process is lacking in Fe and Ni. A dense and uniform coating formed on the alloy following thermal oxidation. The coating is mainly composed of MnCr2O4 spinel phase, while the outer surface of the coating is completely MnCr2O4 spinel. The coating exhibits a favorable thickness of about 7 µm according to SEM and EDS maps of its cross-section. The MnCr2O4 spinel coating significantly affects the coking mechanism and coke property according to coking experiments. Raman spectroscopy shows that the coated sample inhibits catalytic coke formation as more disordered carbon and amorphous carbon layers are present. Moreover, the coating is stable in coking and decoking environments.

The use of a price discrimination strategy is an important tool in competition. It can hurt firms and benefit consumers in a one-sided market. However, in two-sided markets, its primary goal is to attract more agents or increase profits. Here, the performance of a second-degree price discrimination strategy in the context of duopoly two-sided platforms is analysed. Two exogenous variables, which include the discount rate and the price discrimination threshold, are used in order to examine whether the price discrimination strategy could help two-sided platforms achieve their objective, which is to maximise their market value. Three cases are considered, and we demonstrate that the price discrimination strategy cannot attract more agents and at the same time increase the profits; a lower price discrimination threshold cannot ensure larger markets shares; a higher discount rate is detrimental to the profit of a platform. However, this is good for its market shares. Moreover, discriminative pricing increases the competition.

OBJECTIVES:The transoral atlantoaxial reduction plate system treats irreducible atlantoaxial dislocation from transoral atlantoaxial reduction plate-I to transoral atlantoaxial reduction plate-III. However, this system has demonstrated problems associated with screw loosening, atlantoaxial fixation and concealed or manifest neurovascular injuries. This study sought to design a set of individualized templates to improve the accuracy of anterior C2 screw placement in the transoral atlantoaxial reduction plate-IV procedure.METHODS:A set of individualized templates was designed according to thin-slice computed tomography data obtained from 10 human cadavers. The templates contained cubic modules and drill guides to facilitate transoral atlantoaxial reduction plate positioning and anterior C2 screw placement. We performed 2 stages of cadaveric experiments with 2 cadavers in stage one and 8 in stage two. Finally, guided C2 screw placement was evaluated by reading postoperative computed tomography images and comparing the planned and inserted screw trajectories.RESULTS:There were two cortical breaching screws in stage one and three in stage two, but only the cortical breaching screws in stage one were ranked critical. In stage two, the planned entry points and the transverse angles of the anterior C2 screws could be simulated, whereas the declination angles could not be simulated due to intraoperative blockage of the drill bit and screwdriver by the upper teeth.CONCLUSIONS:It was feasible to use individualized templates to guide transoral C2 screw placement. Thus, these drill templates combined with transoral atlantoaxial reduction plate-IV, may improve the accuracy of transoral C2 screw placement and reduce related neurovascular complications.